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KMID : 0371919880010010065
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Journal of Wonju College of Medicine
1988 Volume.1 No. 1 p.65 ~ p.76
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The Exocrine Function and Ultrastructure of Rat Pancreas Treated with Raw Soybean
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Ahn Young-Soo
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Abstract
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This study deals with the effects of soybean trypsin inhibitors, Geodu or Muktae, on the alterations of exocrine functions and ultrastructure in rat pancreas.
The results indicate as follows:
1. Increasing rate of body weight in soybean fed groups was less than that of the control group.
2. Pancreatic weight of soybean treated groups increased significantly, and these effects on the body and pancreatic weight with the diets of Muktae were more profound as compared with the Geodu fed group.
3. The basal and stimulated pancreatic secretions increased after 6-month´s treatment of Muktae and they were the same levle after 9-month´s treatment as compared with the control. Otherwise, these secretions increased continuously in Geodu fed group.
4. Secr?tions of pancreatic enzymes increased in the group of 6-month´s Muktae treatment, and in the group of 9-month´s Geodu treatment by CCK stimulation.
5. On the ultrastructural findings, the stagnation of secretions in acinar lumen and the occlusion of acinar lumen were observed. These soybean-altered characterics were critical in Muktae fed group than in Geodu fed group.
In conclusion, long-term treatment of soybeans inhibited the growth rate, induced pancreatic hypertrophy and raised the level of pancreatic secretion and enzymes. It is suggested that effects of soybeans are dependent upon the content of trypsin inhibitor as well as other factors.
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